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	Provedor de dados BJMBR (1) Autor Meng,Xian-Min (1) Shi,Na (1) Song,Li (1) Wang,Hui (1) Wang,Lin (1) Xu,Rui-Xia (1) Ye,Jue (1) Zhang,Yan-Wan (1) Mais... Palavra-chave CTnI (1) Contraction function (1) Phosphorylation (1) TNNI3K (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I BJMBR Wang,Hui; Wang,Lin; Song,Li; Zhang,Yan-Wan; Ye,Jue; Xu,Rui-Xia; Shi,Na; Meng,Xian-Min. The phosphorylation of cardiac troponin I (cTnI) plays an important role in the contractile dysfunction associated with heart failure. Human cardiac troponin I-interacting kinase (TNNI3K) is a novel cardiac-specific functional kinase that can bind to cTnI in a yeast two-hybrid screen. The purpose of this study was to investigate whether TNNI3K can phosphorylate cTnI at specific sites and to examine whether the phosphorylation of cTnI caused by TNNI3K can regulate cardiac myofilament contractile function. Co-immunoprecipitation was performed to confirm that TNNI3K could interact with cTnI. Kinase assays further indicated that TNNI3K did not phosphorylate cTnI at Ser23/24 and Ser44, but directly phosphorylated Ser43 and Thr143 in vitro. The results obtained... Tipo: Info:eu-repo/semantics/article Palavras-chave: TNNI3K; CTnI; Phosphorylation; Contraction function. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200128 Registros recuperados: 1 Primeira ... 1 ... Última

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